CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14145
Family Name Tyrosine-protein kinase Lck and Mitogen-activated protein kinase 14 inhibitor N-[5-[[2-fluoro-3-(trifluoromethyl)phenyl]carbamoyl]-2-methylphenyl]-4-methoxy-2-(methylamino)pyrimidine-5-carboxamide family
No. of Seeds 2 No. of Other Members 7
Family Centroid CFAMM00426558 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Sphingosine 1-phosphate receptor 5 Binder Superfamily
Class Class 4797

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[(4,6-dim... 1 0


External ID

Functional Category

Molecule Name

CFAMM00426558 CHEMBL255533 Bioactive N-[5-[[2-fluoro-3-(trifluoromethyl)phenyl]carbamoyl]-2-methylphenyl]-4-methoxy-2-(methylamino)pyrimidine-5-carboxamide
CFAMM00426557 CHEMBL257858 Bioactive N-[5-[[2-fluoro-3-(trifluoromethyl)phenyl]carbamoyl]-2-methylphenyl]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



76520 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543