CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14149
Family Name Macrophage colony-stimulating factor 1 receptor and Mast/stem cell growth factor receptor Kit ligand AGN-PC-04UBOL family
No. of Seeds 27 No. of Other Members 4
Family Centroid CFAMM00426583 Functional Category Bioactive
Superfamily Macrophage colony-stimulating factor 1 receptor and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 1031

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 0
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-077MAQ fa... 1 0
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 11
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 1 2
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426584 CHEMBL448117 Bioactive AGN-PC-04UBVJ
CFAMM00426577 CHEMBL452965 Bioactive AGN-PC-050GQZ
CFAMM00426590 CHEMBL255794 Bioactive 8-(2,3-dihydro-1H-inden-5-yl)-2-[4-(3,5-dimethylpiperazin-1-yl)anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
CFAMM00426570 CHEMBL451575 Bioactive AGN-PC-04UBOM
CFAMM00426583 CHEMBL505830 Bioactive AGN-PC-04UBOL
CFAMM00426576 CHEMBL444454 Bioactive AGN-PC-050GQY
CFAMM00426589 CHEMBL404188 Bioactive 8-(2,3-dihydro-1H-inden-5-yl)-2-[4-(2-morpholin-4-ylethyl)anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
CFAMM00426569 CHEMBL445519 Bioactive AGN-PC-050GR0
CFAMM00426575 CHEMBL455591 Bioactive AGN-PC-050GQW
CFAMM00426588 CHEMBL509044 Bioactive AGN-PC-04UBS1
CFAMM00426581 CHEMBL257528 Bioactive 8-(2,3-dihydro-1H-inden-5-yl)-5-oxo-2-(4-piperidin-4-ylanilino)pyrido[2,3-d]pyrimidine-6-carboxamide
CFAMM00426574 CHEMBL256459 Bioactive 8-(2,3-dihydro-1H-inden-5-yl)-2-[4-[2-(dimethylamino)ethyl]anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
CFAMM00426587 CHEMBL451931 Bioactive AGN-PC-04UC90
CFAMM00426580 CHEMBL489298 Bioactive AGN-PC-04UBYY
CFAMM00426593 CHEMBL451918 Bioactive AGN-PC-04UBS3
CFAMM00426573 CHEMBL402852 Bioactive 8-(2,3-dihydro-1H-inden-5-yl)-5-oxo-2-[3-(piperidine-1-carbonyl)anilino]pyrido[2,3-d]pyrimidine-6-carboxamide
CFAMM00426586 CHEMBL255584 Bioactive 8-(2,3-dihydro-1H-inden-5-yl)-2-[3-(4-methylpiperazin-1-yl)anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
CFAMM00426592 CHEMBL271461 Bioactive 8-(2,3-dihydro-1H-inden-5-yl)-5-oxo-2-(4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidine-6-carboxamide
CFAMM00426585 CHEMBL522834 Bioactive AGN-PC-04UC2I
CFAMM00426578 CHEMBL508935 Bioactive AGN-PC-050GQX
CFAMM00426591 CHEMBL492809 Bioactive AGN-PC-04T5ZZ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44452 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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