CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14158
Family Name Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-but-2-ynyl-5-[(3-methylisoquinolin-1-yl)methyl]imidazo[4,5-d]pyridazin-4-one family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00426703 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 Binder Superfamily 4
Class Class 1027

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Dipeptidyl peptidase 4 inhibitor Xanthine mimetic compound 8 f... 2 2
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 4 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426704 CHEMBL255709 Bioactive 2-(3-aminopiperidin-1-yl)-3-but-2-ynyl-7-methyl-5-[(3-methylisoquinolin-1-yl)methyl]imidazo[4,5-d]pyridazin-4-one
CFAMM00426703 CHEMBL256521 Bioactive 2-(3-aminopiperidin-1-yl)-3-but-2-ynyl-5-[(3-methylisoquinolin-1-yl)methyl]imidazo[4,5-d]pyridazin-4-one
CFAMM00426701 CHEMBL257376 Bioactive 2-(2-aminoethylamino)-3-but-2-ynyl-5-[(4-methylquinazolin-2-yl)methyl]imidazo[4,5-d]pyridazin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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