CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14161
Family Name Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-ylethyl)phenyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole family
No. of Seeds 8 No. of Other Members 4
Family Centroid CFAMM00426734 Functional Category Bioactive
Superfamily Histamine H3 receptor Binder Superfamily 12
Class Class 4783

Cousin Family NamesSeedsMembers
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Zicronapine family 43 62
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Histamine H3 receptor ligand SureCN1641166 family 3 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Histamine H3 receptor ligand [(3aR,6aR)-4-[4-[2-[(2R)-2-methyl... 6 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Histamine H3 receptor ligand SureCN3052824 family 4 14


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426734 CHEMBL255752 Bioactive 2-benzyl-4-[4-(2-pyrrolidin-1-ylethyl)phenyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole
CFAMM00426727 CHEMBL273202 Bioactive 2-[4-(2-benzyl-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrol-4-yl)phenyl]-N,N-dimethylethanamine
CFAMM00426732 CHEMBL402296 Bioactive 2-benzyl-4-[4-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]phenyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole
CFAMM00426731 CHEMBL256648 Bioactive 4-[4-[2-(azetidin-1-yl)ethyl]phenyl]-2-benzyl-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole
CFAMM00426730 CHEMBL255962 Bioactive 2-benzyl-4-[4-[2-(2-methylpyrrolidin-1-yl)ethyl]phenyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole
CFAMM00426736 CHEMBL270011 Bioactive (3aR,6aR)-2-benzyl-4-[4-(2-pyrrolidin-1-ylethyl)phenyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole
CFAMM00426729 CHEMBL256225 Bioactive 2-benzyl-4-[4-(2-piperidin-1-ylethyl)phenyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole
CFAMM00426728 CHEMBL409899 Bioactive (3aS,6aS)-2-benzyl-4-[4-(2-pyrrolidin-1-ylethyl)phenyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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