CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14173
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand [4-(4-chlorophenoxy)-3-(methylaminomethyl)phenyl]-(4-cyclopropyl-1,4-diazepan-1-yl)methanone family
No. of Seeds 14 No. of Other Members 3
Family Centroid CFAMM00275628 Functional Category Bioactive
Superfamily Sodium-dependent serotonin transporter and C-C chemokine receptor type 1 Binder Superfamily
Class Class 2895

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
5-hydroxytryptamine receptor 3A Ligand KB-6806 Family 12 11
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Histamine H3 receptor Ligand A-317920 Family 9 240
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
D(4) dopamine receptor ligand AGN-PC-00FVZ6 family 1 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prothrombin inhibitor AGN-PC-09QMX5 family 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Melanin-concentrating hormone receptor 1 ligand N-[1-[3-(4-chl... 1 1
Orexin receptor type 2 ligand (4-chlorophenyl)-[(3R,5S)-3,5-di... 1 2
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 6 14
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 2 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 11 15
C-C chemokine receptor type 1 ligand 2-[(2S)-3-(5-chlorospiro[... 2 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07R5XZ family 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Histamine H1 receptor and C-C chemokine receptor type 3 ligand... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426783 CHEMBL272077 Bioactive [4-(4-chlorophenoxy)-3-(methylaminomethyl)phenyl]-(4-propan-2-yl-1,4-diazepan-1-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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