CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14188
Family Name C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyphenyl)-4-phenylimidazol-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00426906 Functional Category Bioactive
Superfamily C-C chemokine receptor type 5 Ligand Cenicriviroc Superfamily
Class Class 875

Cousin Family NamesSeedsMembers
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04S3QV family 1 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00426901 CHEMBL257209 Bioactive N-[(1R)-1-[1-(4-ethoxyphenyl)-4-phenylimidazol-2-yl]ethyl]-N-(3-ethylsulfonylpropyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00426906 CHEMBL256589 Bioactive N-[(1R)-1-[1-(4-ethoxyphenyl)-4-phenylimidazol-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00426905 CHEMBL256585 Bioactive N-[(1R)-1-[1-(4-ethoxyphenyl)-4-phenylimidazol-2-yl]ethyl]-N-(2-ethylsulfonylethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
CFAMM00426904 CHEMBL269932 Bioactive N-[(1R)-1-[1-(4-ethoxyphenyl)imidazol-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-(pyridin-3-ylmethyl)acetamide
CFAMM00426909 CHEMBL403378 Bioactive N-[(1R)-1-[1-(4-ethoxyphenyl)-4-phenylimidazol-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[[(2S)-1-methylpyrrolidin-2-yl]methyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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