CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14200
Family Name Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00427047 Functional Category Bioactive
Superfamily Orexin receptor type 2 and Orexin receptor type 1 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Histamine H1 receptor Ligand Mizolastine Family 14 603
Growth hormone receptor Ligand EP-51216 Family 34 390
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... 8 90
Histamine H4 receptor ligand SureCN602132 family 1 8
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1H-benzimidazo... 3 5
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1-phenylimidaz... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 5 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Tyrosine-protein phosphatase non-receptor type 1 ligand sodium... 1 44
Putative Bioactive N-[(2R)-2-[(2S)-2-(1H-benzimidazol-2-yl)pyr... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Lysosomal Pro-X carboxypeptidase inhibitor 9H-fluoren-9-ylmeth... 1 1
Tyrosine-protein phosphatase non-receptor type 1 ligand sodium... 2 6
Sterol O-acyltransferase 1 inhibitor AGN-PC-025JYX family 1 1
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 1 15


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427047 CHEMBL256789 Bioactive (2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
CFAMM00427045 CHEMBL429848 Bioactive (2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27409 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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