CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14204
Family Name C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(trifluoromethyl)quinolin-2-yl]amino]-8-azabicyclo[3.2.1]octan-8-yl]methyl]-9-azabicyclo[3.3.1]non-3-en-9-yl]ethanone family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00427066 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Beta-secretase 1 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Prothrombin inhibitor SureCN7371121 family 13 3
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427068 CHEMBL257017 Bioactive 1-[3-[[(1S,5R)-3-[[6-(trifluoromethyl)quinolin-2-yl]amino]-8-azabicyclo[3.2.1]octan-8-yl]methyl]-9-azabicyclo[3.3.1]non-3-en-9-yl]ethanone
CFAMM00427067 CHEMBL271847 Bioactive 1-[3-[[4-[[7-(trifluoromethyl)quinolin-2-yl]amino]piperidin-1-yl]methyl]-9-azabicyclo[3.3.1]non-3-en-9-yl]ethanone
CFAMM00427066 CHEMBL256851 Bioactive 1-[3-[[(1R,5S)-3-[[7-(trifluoromethyl)quinolin-2-yl]amino]-8-azabicyclo[3.2.1]octan-8-yl]methyl]-9-azabicyclo[3.3.1]non-3-en-9-yl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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