CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14222
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand (4-cyclopropyl-1,4-diazepan-1-yl)-[3-(methylaminomethyl)-4-(4-methylsulfanylphenoxy)phenyl]methanone family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00427183 Functional Category Bioactive
Superfamily Peroxisome proliferator-activated receptor gamma and Peroxisome proliferator-activated receptor alpha Ligand KRP-297 Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Histamine H3 receptor Ligand A-317920 Family 9 240
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 0


External ID

Functional Category

Molecule Name

CFAMM00427185 CHEMBL409877 Bioactive (4-cyclopropylpiperazin-1-yl)-[3-(methylaminomethyl)-4-(3-methyl-4-methylsulfanylphenoxy)phenyl]methanone
CFAMM00427184 CHEMBL267267 Bioactive [3-(methylaminomethyl)-4-(4-methylsulfanylphenoxy)phenyl]-(4-propan-2-yl-1,4-diazepan-1-yl)methanone
CFAMM00427183 CHEMBL257434 Bioactive (4-cyclopropyl-1,4-diazepan-1-yl)-[3-(methylaminomethyl)-4-(4-methylsulfanylphenoxy)phenyl]methanone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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