CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14225
Family Name Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-[[[(2S)-2-carboxy-2-hydroxyethyl]-(2-methylpropyl)carbamoyl]amino]-3-naphthalen-2-ylpropanoic acid family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00235045 Functional Category Bioactive
Superfamily Neprilysin and Cathepsin D Binder Superfamily
Class Class 607

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme inhibitor Phosphonate-containing... 7 41
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Renin Inhibitor CP-80794 Family 16 112
Neprilysin Inhibitor Thiorphan Family 41 68
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Aminopeptidase N and Neprilysin inhibitor (2S)-2-[[(2S)-2-[[[(... 1 0
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Neprilysin inhibitor SureCN489232 family 3 9
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Renin inhibitor 2-hydroxy-3-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Angiotensin-converting enzyme inhibitor (2S,4R)-1-[(2S)-6-amin... 3 1
Type-2 angiotensin II receptor ligand SureCN3515167 family 2 0
Neprilysin inhibitor SureCN7437961 family 2 6
Pol polyprotein inhibitor AC1L9R8I family 1 0
Renin inhibitor 2-methylpropyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl... 14 0
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Angiotensin-converting enzyme inhibitor (2S)-2-[[[(2S)-2-carbo... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427197 CHEMBL257251 Bioactive (2S)-2-[[2-methylpropyl(2-phosphonoethyl)carbamoyl]amino]-3-naphthalen-2-ylpropanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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