CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14235
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-methyl-2-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]naphthalen-1-amine family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00427234 Functional Category Bioactive
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 3082

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Type-2 angiotensin II receptor Ligand SC-50560 Family 3 84
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13680... 1 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Type-1 angiotensin II receptor and Cytochrome P450 2C19 ligand... 2 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 17 10
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 4 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-met... 11 12
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-... 4 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-(2-... 4 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3,5-b... 4 6
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A3 ligand SureCN6716937 family 1 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 17 0
Aurora kinase A inhibitor SureCN2205392 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427233 CHEMBL435855 Bioactive SureCN7327490
CFAMM00427234 CHEMBL257601 Bioactive N-methyl-2-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]naphthalen-1-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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