CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14249
Family Name Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(3,4-dichloro-N-methylanilino)-N-methyl-N-[(1R)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00305305 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 19
Class Class 2396

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 4 18
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanin-concentrating hormone receptor 1 ligand 4-(4-chlorophe... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
C-C chemokine receptor type 5 ligand AC1MHYGF family 3 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GBV family 1 0
Translocator protein inhibitor CHEMBL2332254 family 6 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Kappa-type opioid receptor ligand AGN-PC-077Q4Y family 5 9
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 6,7-dichlo... 2 0
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Progesterone receptor ligand CHEMBL403139 family 2 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 3
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Glycogen phosphorylase, liver form inhibitor TCMDC-135759 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427295 CHEMBL488635 Bioactive 2-(3,4-dichloro-N-methylanilino)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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