CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFBM1425
Family Name Platelet-activating factor receptor ligand SureCN9384429 family
No. of Seeds 11 No. of Other Members 3
Family Centroid CFAMM00323246 Functional Category Bioactive
Superfamily Platelet-activating factor receptor and Gamma-aminobutyric acid receptor subunit beta-3 Binder Superfamily
Class Class 1377

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
HER Inhibitor AC480 Family 4 67
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
Tedizolid family 2 2
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor CI-9... 3 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 9 16
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 55
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9384481 family 2 0
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Smoothened homolog inhibitor SureCN1091571 family 2 2
Transient receptor potential cation channel subfamily V member... 1 0
Transient receptor potential cation channel subfamily V member... 1 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Histamine H3 receptor ligand SureCN4025673 family 4 2
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Insulin-like growth factor 1 receptor and Insulin receptor lig... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-chlorophenyl)pyrazo... 2 0
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 2 10
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Prothrombin inhibitor 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-y... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Cannabinoid receptor 1 ligand SureCN4819820 family 11 5
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Cholecystokinin receptor type A ligand 6-[2-[2-(cyclohexylmeth... 2 6
Aurora kinase A and Aurora kinase B inhibitor N-[6-methyl-3-[1... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Growth hormone secretagogue receptor type 1 and Muscarinic ace... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Renin inhibitor AGN-PC-073MLF family 7 6
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Substance-P receptor ligand SureCN7659714 family 2 0
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-09QXA7 fa... 16 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 1 3
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Histone deacetylase 1 and Proto-oncogene tyrosine-protein kina... 4 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 6 1
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
Glycogen synthase kinase-3 beta inhibitor GSK-3beta Inhibitor ... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Platelet-activating factor receptor ligand 1,8-dimethyl-5-[4-(... 1 0
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Fatty-acid amide hydrolase 1 and Liver carboxylesterase 1 inhi... 1 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Cannabinoid receptor 1 ligand AGN-PC-07R9T4 family 27 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00323261 CHEMBL327034 Bioactive 1-methyl-5-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-3-phenyl-2,6-dihydropyrazolo[3,4-b][1,4]diazepin-7-one
CFAMM00323251 CHEMBL420527 Bioactive CHEMBL420527
CFAMM00323259 CHEMBL118793 Bioactive 1,8-dimethyl-5-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-3-propan-2-yl-6H-pyrazolo[3,4-b][1,4]diazepin-7-one
CFAMM00323250 CHEMBL116938 Bioactive SureCN9383212
CFAMM00323257 CHEMBL324121 Bioactive 3-(4-chlorophenyl)-1,8-dimethyl-5-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-6H-pyrazolo[3,4-b][1,4]diazepin-7-one
CFAMM00323256 CHEMBL332448 Bioactive 1,8-dimethyl-5-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-3-pyridin-4-yl-6H-pyrazolo[3,4-b][1,4]diazepin-7-one
CFAMM00323248 CHEMBL331124 Bioactive CHEMBL331124
CFAMM00323255 CHEMBL432832 Bioactive 1,3,4-trimethyl-7-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-6H-pyrazolo[3,4-b][1,4]diazepin-5-one
CFAMM00323254 CHEMBL120515 Bioactive 1-methyl-7-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-3-phenyl-4,6-dihydropyrazolo[3,4-b][1,4]diazepin-5-one
CFAMM00323246 CHEMBL119371 Bioactive SureCN9384429
CFAMM00323262 CHEMBL431664 Bioactive SureCN9386282

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27408 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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