CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14257
Family Name Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl]acetamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00427319 Functional Category Bioactive
Superfamily Cannabinoid receptor 1 Ligand AZD2207 Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Amg 423 family 7 47
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Prothrombin inhibitor 2-[6-cyano-3-[[2,2-difluoro-2-(3-methylp... 10 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 1 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Androgen receptor ligand 4-(1-benzyl-2-oxoimidazo[4,5-b]pyridi... 1 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427318 CHEMBL371309 Bioactive 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-ylethyl)imino-1-hydroxypyridin-2-yl]-N-[(3-fluoropyridin-2-yl)methyl]acetamide
CFAMM00427319 CHEMBL258018 Bioactive N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26238 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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