CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14261
Family Name Kappa-type opioid receptor and Delta-type opioid receptor ligand 2-(3,4-dimethoxyphenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide family
No. of Seeds 1 No. of Other Members 3
Family Centroid CFAMM00142451 Functional Category Bioactive with Natural Product
Superfamily Kappa-type opioid receptor and Niemann-Pick C1 protein Binder Superfamily
Class Class 3612

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Zucapsacin family 7 177
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Substance-P receptor Ligand DA-5018 Family 14 73
D(3) dopamine receptor Ligand U-99194A Family 7 33
Ivabradine family 1 11
Elagolix family 43 98
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Kappa-type opioid receptor Ligand ICI-204448 Family 7 26
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Pyruvate kinase PKM and Pyruvate kinase PKLR inhibitor MLS0022... 1 0
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Transient receptor potential cation channel subfamily V member... 3 18
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 12
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 12 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Substance-P receptor ligand SureCN9054944 family 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor 4-(3... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 0
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 4 3
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor meth... 1 1
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
6,7-dihydropyrimido[6,1-a]isoquinolin-4-one NP ZINC02112138 Fa... 10 0
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 2
3-benzazepin-2-one NP 7,8-dimethoxy-1h-benzo[d]azepin-2(3h)-on... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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