CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14262
Family Name Coagulation factor X inhibitor AGN-PC-078Y0S family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00427338 Functional Category Bioactive
Superfamily Coagulation factor X and C-X-C chemokine receptor type 3 Binder Superfamily
Class Class 2337

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-chlorop... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
ALK tyrosine kinase receptor and Insulin receptor ligand 2-[[5... 1 0
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[7-bromo-3... 1 0
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427334 CHEMBL514667 Bioactive AGN-PC-078Y0Q
CFAMM00427340 CHEMBL403075 Bioactive N-(5-chloropyridin-2-yl)-5-cyano-2-[[4-(2-oxopiperidin-1-yl)benzoyl]amino]benzamide
CFAMM00427339 CHEMBL475553 Bioactive N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-ethynylbenzamide
CFAMM00427338 CHEMBL516082 Bioactive AGN-PC-078Y0S
CFAMM00427337 CHEMBL428432 Bioactive N-(5-chloropyridin-2-yl)-5-(methanesulfonamido)-2-[[4-(2-oxopiperidin-1-yl)benzoyl]amino]benzamide
CFAMM00427336 CHEMBL258188 Bioactive N-(5-chloropyridin-2-yl)-5-cyano-2-[[4-(2-oxopyridin-1-yl)benzoyl]amino]benzamide
CFAMM00427335 CHEMBL258196 Bioactive N-(5-chloropyridin-2-yl)-5-(methanesulfonamido)-2-[[4-(2-oxopyridin-1-yl)benzoyl]amino]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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