CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14275
Family Name Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]pentanoylamino]-4-oxo-5-phenoxypentanoic acid family
No. of Seeds 13 No. of Other Members 5
Family Centroid CFAMM00427433 Functional Category Bioactive
Superfamily Elagolix Superfamily
Class Class 1003

Cousin Family NamesSeedsMembers
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Tyrosine-protein kinase Lck inhibitor (4S)-5-[(4-methoxyphenyl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427431 CHEMBL25864 Bioactive (3S)-3-[[2-[6-benzyl-3-(naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]acetyl]amino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427424 CHEMBL25925 Bioactive (3S)-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427430 CHEMBL282198 Bioactive (3S)-3-[2-[3-(naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]hexanoylamino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427436 CHEMBL553107 Bioactive 3-[[(2S)-1-[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427429 CHEMBL418573 Bioactive (3S)-3-[2-[3-(naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]propanoylamino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427422 CHEMBL25943 Bioactive SureCN8247270
CFAMM00427435 CHEMBL26088 Bioactive (3S)-3-[[3-methoxy-2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]propanoyl]amino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427428 CHEMBL287440 Bioactive (3S)-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]pent-4-enoylamino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427421 CHEMBL286519 Bioactive 3-[[(2S)-1-[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]piperidine-2-carbonyl]amino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427434 CHEMBL26719 Bioactive (3S)-3-[[2-[3-(naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]-2-phenylacetyl]amino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427427 CHEMBL26413 Bioactive (3S)-3-[2-[3-(naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427433 CHEMBL284219 Bioactive (3S)-3-[2-[3-(naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]pentanoylamino]-4-oxo-5-phenoxypentanoic acid
CFAMM00427426 CHEMBL26544 Bioactive 3-[[(2S)-2-[[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]amino]propanoyl]amino]-4-oxo-5-phenoxypentanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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