CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14286
Family Name Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amino-4-(1,3-benzodioxol-5-yl)-6-phenylpyrimidine-5-carbonitrile family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00427506 Functional Category Bioactive with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A3 Binder Superfamily 7
Class Class 377

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Adenosine receptor A1 Ligand LUF-5853 Family 2 8
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dual specificity protein kinase CLK4 and Dual specificity tyro... 1 14
Adenosine kinase inhibitor SureCN8134468 family 3 7
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Adenosine kinase inhibitor SureCN8139139 family 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Adenosine receptor A1 ligand BAS 00727702 family 1 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Dual specificity protein kinase CLK4 and Dual specificity prot... 1 0
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
TGF-beta receptor type-1 ligand AGN-PC-07CRDB family 5 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427506 CHEMBL259607 Bioactive 2-amino-4-(1,3-benzodioxol-5-yl)-6-phenylpyrimidine-5-carbonitrile
CFAMM00427503 CHEMBL434771 Bioactive 5-(1,3-benzodioxol-5-yl)-6-ethylpyrimidine-2,4-diamine
CFAMM00427502 CHEMBL386316 Bioactive alkynylpyrimidine 5

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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