CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14294
Family Name Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-3 beta inhibitor pyrazolopyridazine deriv. 11 family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00427561 Functional Category Bioactive
Superfamily Cyclin-A2 and Beta-lactamase Binder Superfamily
Class Class 5019

Cousin Family NamesSeedsMembers
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Aurora kinase B and Aurora kinase A Inhibitor PHA-739358 Family 6 29
Cyclin-dependent kinase 2 Inhibitor N-(5-cyclopropyl-1h-pyrazo... 6 62
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Glycogen synthase kinase-3 beta Inhibitor N-(6-chloro-5-p-toly... 5 9
Glycogen synthase kinase-3 beta Inhibitor (e)-n-(6-(prop-1-eny... 3 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 7 21
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
Aurora kinase A inhibitor SureCN3894803 family 5 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 10 9
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 6
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 4 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(6-ph... 2 0
Neuropeptide Y receptor type 5 ligand N-[5-(4-chlorophenyl)-1H... 1 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-[6,6-dimet... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427561 CHEMBL409738 Bioactive pyrazolopyridazine deriv. 11
CFAMM00427560 CHEMBL261518 Bioactive pyrazolopyridazine deriv. 12
CFAMM00427567 CHEMBL406125 Bioactive SB-678557-A
CFAMM00427566 CHEMBL259271 Bioactive pyrazolopyridazine deriv. 14

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44307 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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