CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14299
Family Name Vascular endothelial growth factor receptor 2 ligand 6-(6,7-dimethoxyquinolin-4-yl)oxy-N-(5-methyl-1,2-oxazol-3-yl)naphthalene-1-carboxamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00427585 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 and Cellular tumor antigen p53 Binder Superfamily
Class Class 211

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Tivozanib family 4 6
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4C and cAMP-speci... 12 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
B2 bradykinin receptor ligand SureCN8516699 family 3 2
B2 bradykinin receptor ligand SureCN6640854 family 7 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Hepatocyte growth factor receptor and Vascular endothelial gro... 14 10
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Transient receptor potential cation channel subfamily V member... 3 2
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427586 CHEMBL270978 Bioactive 6-(6,7-dimethoxyquinolin-4-yl)oxy-N-(3-methyl-1,2-oxazol-5-yl)naphthalene-1-carboxamide
CFAMM00427585 CHEMBL259461 Bioactive 6-(6,7-dimethoxyquinolin-4-yl)oxy-N-(5-methyl-1,2-oxazol-3-yl)naphthalene-1-carboxamide
CFAMM00427584 CHEMBL408478 Bioactive N-(5-tert-butyl-1,2-oxazol-3-yl)-6-(6,7-dimethoxyquinolin-4-yl)oxynaphthalene-1-carboxamide
CFAMM00427587 CHEMBL409538 Bioactive 6-(6,7-dimethoxyquinolin-4-yl)oxy-N-(1,2-oxazol-3-yl)naphthalene-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27269 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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