CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Endothelin-converting enzyme 1 inhibitor 2-[[1-[[(2S)-4-methyl-2-sulfanylpentanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acid family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00307945 Functional Category Bioactive
Superfamily Integrin beta-3 Inhibitor Elarofiban Superfamily
Class Class 134

Cousin Family NamesSeedsMembers
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Substance-P receptor Ligand GSK424887 Family 8 184
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Endothelin B receptor Ligand IRL-2500 Family 34 87
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor 3-[[1-(3-pipe... 3 0
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 2 3


External ID

Functional Category

Molecule Name

CFAMM00307943 CHEMBL317472 Bioactive (2S)-2-[[1-[[(2S)-4-methyl-2-sulfanylpentanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-2-ylpyridin-3-yl)propanoic acid
CFAMM00307945 CHEMBL102527 Bioactive 2-[[1-[[(2S)-4-methyl-2-sulfanylpentanoyl]amino]cyclopentanecarbonyl]amino]-3-(6-thiophen-3-ylpyridin-3-yl)propanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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