CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14300
Family Name Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-methylsulfonylphenyl)-6-N-(thiophen-2-ylmethyl)pyrimidine-4,6-diamine family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00427594 Functional Category Bioactive
Superfamily Glucosylceramidase and Prostaglandin G/H synthase 2 Binder Superfamily
Class Class 1151

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
PF-3758309 family 1 8
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
5-hydroxytryptamine receptor 6 ligand 3-(5-chlorothiophen-2-yl... 6 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
5-hydroxytryptamine receptor 6 ligand 3-(3-chlorophenyl)sulfon... 8 1
5-hydroxytryptamine receptor 6 ligand 3-(3-bromophenyl)sulfony... 3 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-076AT1 family 7 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Prostaglandin G/H synthase 2 inhibitor 6-ethoxy-2-(4-methylsul... 5 1
Prostaglandin G/H synthase 2 inhibitor 2-(4-methylsulfonylphen... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Growth hormone secretagogue receptor type 1 ligand AGN-PC-00CN... 1 2
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Aurora kinase A and Vascular endothelial growth factor recepto... 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427591 CHEMBL403957 Bioactive N-[(5-chlorothiophen-2-yl)methyl]-2-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-4-amine
CFAMM00427590 CHEMBL272433 Bioactive 6-ethylsulfanyl-2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
CFAMM00427589 CHEMBL270078 Bioactive 6-chloro-2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
CFAMM00427595 CHEMBL405564 Bioactive 2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
CFAMM00427594 CHEMBL259468 Bioactive 4-N,4-N-diethyl-2-(4-methylsulfonylphenyl)-6-N-(thiophen-2-ylmethyl)pyrimidine-4,6-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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