CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1431
Family Name Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(phenylmethoxycarbonylamino)butanoyl]-2,3-dihydroindole-2-carboxylic acid family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00323323 Functional Category Bioactive
Superfamily Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(phenylmethoxycarbonylamino)butanoyl]-2,3-dihydroindole-2-carboxylic acid Superfamily
Class Class 1500

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
Flovagatran family 12 546
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Cyclophilin receptor and Cyclosporine receptor Ligand D-43787 ... 2 13
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(n-phenylamino)pheny... 2 3
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Caspase-3 and Caspase-1 inhibitor (4S)-5-[[(2S)-1-[[(3S)-2-hyd... 1 2
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Prolyl endopeptidase inhibitor benzyl (2R)-2-[(2S)-2-formylpyr... 2 1
Prolyl endopeptidase and Chymotrypsin-like elastase family mem... 3 9
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Angiotensin-converting enzyme inhibitor AGN-PC-074KD3 family 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Angiotensin-converting enzyme inhibitor (2S)-1-[(2S)-2-sulfany... 7 23
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 2 0
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Prolyl endopeptidase inhibitor benzyl (1R,2S)-2-[(2S)-2-formyl... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-4-methyl... 8 22
Pol polyprotein inhibitor AC1LADQG family 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Dipeptidyl peptidase 4 inhibitor 2-cyanopyrrolidine 24b family 1 1
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Angiotensin-converting enzyme inhibitor 1-[(2R,4R)-4-carboxy-2... 2 3
Neutrophil elastase inhibitor 1-O-benzyl 4-O-ethyl (3aS,6R,6aR... 3 4
Caspase-9 and Caspase-8 inhibitor 4-fluoro-2-[[2-[[(2S)-3-meth... 1 11
Angiotensin-converting enzyme inhibitor 2-(N-[(2S)-6-amino-2-[... 2 1
Protease inhibitor AC1O54RX family 2 4
Solute carrier family 12 member 5 inhibitor AGN-PC-07ZCLM family 1 12
Solute carrier family 12 member 5 inhibitor benzyl 1-acetyl-2-... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-[(4-meth... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00323325 CHEMBL40435 Bioactive (2s,3as,7as)-1-[(4r)-4-{[(benzyloxy)carbonyl]amino}-4-carboxybutanoyl]octahydro-1h-indole-2-carboxylic acid(non-preferred name)
CFAMM00323324 CHEMBL40885 Bioactive (2R)-5-[(2S)-2-[2-(dimethylamino)ethoxycarbonyl]-2,3-dihydroindol-1-yl]-5-oxo-2-(phenylmethoxycarbonylamino)pentanoic acid
CFAMM00323323 CHEMBL1169570 Bioactive (2R)-1-[4-carboxy-4-(phenylmethoxycarbonylamino)butanoyl]-2,3-dihydroindole-2-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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