CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14314
Family Name Mitogen-activated protein kinase 8 inhibitor 6-chloro-2-[[5-methylsulfonyl-1-(2-oxopropyl)pyrazol-3-yl]methyl]-4-phenyl-3-propanoylisoquinolin-1-one family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00427411 Functional Category Bioactive
Superfamily Cannabinoid receptor 2 Ligand SR144528 Superfamily
Class Class 1648

Cousin Family NamesSeedsMembers
Coagulation factor X inhibitor SureCN8169809 family 12 18
Mitogen-activated protein kinase 8 inhibitor 5-[(6-chloro-1-ox... 5 7
Thyroid hormone receptor beta ligand GNF-Pf-2391 family 1 0


External ID

Functional Category

Molecule Name

CFAMM00427667 CHEMBL261413 Bioactive 6-chloro-2-[[1-(3-hydroxy-3-methylbutyl)-5-methylsulfonylpyrazol-3-yl]methyl]-4-phenyl-3-propanoylisoquinolin-1-one
CFAMM00427666 CHEMBL260065 Bioactive 2-[3-[(6-chloro-1-oxo-4-phenyl-3-propanoylisoquinolin-2-yl)methyl]-5-methylsulfonylpyrazol-1-yl]acetamide
CFAMM00427665 CHEMBL411083 Bioactive 6-chloro-2-[[1-(2,2-difluoroethyl)-5-methylsulfonylpyrazol-3-yl]methyl]-4-phenyl-3-propanoylisoquinolin-1-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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