CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14316
Family Name Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protein kinase Lck inhibitor 5-cyclopropyl-2-(3,5-dimethoxyanilino)-7-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide family
No. of Seeds 5 No. of Other Members 12
Family Centroid CFAMM00427675 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase Binder Superfamily 4
Class Class 1144

Cousin Family NamesSeedsMembers
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Tyrosine-protein kinase SYK and Lysine--tRNA ligase inhibitor ... 8 8
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8


External ID

Functional Category

Molecule Name

CFAMM00427681 CHEMBL261188 Bioactive 5-cyclopropyl-2-(3,5-dimethoxyanilino)-7-[[(2S)-1-hydroxy-3-pyridin-3-ylpropan-2-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CFAMM00427685 CHEMBL260157 Bioactive 5-cyclopropyl-2-(3,5-dimethoxyanilino)-7-[[(2S)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CFAMM00427683 CHEMBL261743 Bioactive 5-cyclopropyl-2-(3,5-dimethoxyanilino)-7-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CFAMM00427676 CHEMBL406418 Bioactive 5-cyclopropyl-2-(3,5-dimethoxyanilino)-7-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CFAMM00427675 CHEMBL260861 Bioactive 5-cyclopropyl-2-(3,5-dimethoxyanilino)-7-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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