CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14319
Family Name Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protein kinase Src inhibitor CHEMBL260956 family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00427694 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Beta-lactamase Binder Superfamily
Class Class 2504

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
AP26113 family 16 90
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Glycogen synthase kinase-3 alpha and Casein kinase II subunit ... 1 16
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Gastrin/cholecystokinin type B receptor ligand AGN-PC-077L8M f... 24 10
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Tyrosine-protein kinase SYK and Lysine--tRNA ligase inhibitor ... 8 8
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427697 CHEMBL260306 Bioactive CHEMBL260306
CFAMM00427694 CHEMBL260956 Bioactive CHEMBL260956

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27634 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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