CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14325
Family Name Mitogen-activated protein kinase 14 inhibitor ethyl 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00427726 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 11 Binder Superfamily 4
Class Class 195

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
PHA848125 family 13 138
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Cartazo... 11 105
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
Vascular endothelial growth factor receptor 2 ligand SureCN405... 2 8
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427726 CHEMBL260447 Bioactive ethyl 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
CFAMM00427725 CHEMBL261007 Bioactive 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26190 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543