CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14326
Family Name Beta-secretase 1 and Cathepsin D inhibitor (4S)-N-[(2S,3R)-4-[(3-tert-butylphenyl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-1-[(3,5-difluorophenyl)methyl]-2-oxoimidazolidine-4-carboxamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00232288 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin D Binder Superfamily 2
Class Class 3550

Cousin Family NamesSeedsMembers
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Pol polyprotein inhibitor (2S)-2-[[2-(2,5-dioxoimidazolidin-4-... 2 0
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Pol polyprotein inhibitor penicillin deriv. 69 family 1 1
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonyl... 2 0
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
Cytochrome P450 3A4 and Beta-secretase 1 inhibitor N-[(2S,3R)-... 2 40
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LAMTL family 11 15
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cy... 2 0
Pol polyprotein inhibitor 4-benzyl-N-[(2S)-1-[[(2S,3R,4S,5S)-5... 3 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor (2R,3R)... 1 0
Beta-secretase 1 inhibitor SureCN8292004 family 1 0
Sodium-dependent noradrenaline transporter inhibitor SureCN408... 5 12
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(3R)... 1 0
Cathepsin D and Beta-secretase 1 inhibitor benzyl 3-[[(2R,3S)-... 1 0
Cathepsin D and Beta-secretase 1 inhibitor N-[(2S,3R)-4-[[1-(3... 1 0
Cathepsin D and Beta-secretase 1 inhibitor N-[(2S,3R)-4-[[1-[3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427727 CHEMBL491660 Bioactive SureCN12742808

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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