CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14330
Family Name 5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-5-fluoro-1H-indol-2-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00427735 Functional Category Bioactive
Superfamily Melanocortin receptor 4 and Prelamin-A/C Binder Superfamily
Class Class 1375

Cousin Family NamesSeedsMembers
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Neuropeptide Y receptor type 2 ligand N-[3-chloro-4-[2-(cyclop... 1 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Aldose reductase inhibitor Spiro-cimqat family 6 8
Interleukin-8 inhibitor 2-[2-(2,6-dichloroanilino)phenyl]-N-me... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427735 CHEMBL260761 Bioactive 7-chloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-5-fluoro-1H-indol-2-one
CFAMM00427734 CHEMBL260870 Bioactive 5,7-dichloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-1H-indol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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