CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14343
Family Name Hepatocyte growth factor receptor and Protein-tyrosine kinase 2-beta ligand SU11274 family
No. of Seeds 2 No. of Other Members 15
Family Centroid CFAMM00388685 Functional Category Bioactive
Superfamily Integrin beta-2 and P2X purinoceptor 7 Binder Superfamily
Class Class 1340

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
D(3) dopamine receptor Ligand SB-277011 Family 13 178
C-C chemokine receptor type 9 Ligand Vercirnon Family 1 1
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-phen... 10 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Aurora kinase A and Aurora kinase B inhibitor SureCN3802769 fa... 2 20
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Survival motor neuron protein and Menin inhibitor CHEMBL130937... 1 7
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Hepatocyte growth factor receptor ligand 5-[(2,6-dichloropheny... 2 1
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 3
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 1 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
B1 bradykinin receptor ligand AGN-PC-00RZQU family 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
C-C chemokine receptor type 8 ligand ethyl 4-[[4-(pyridine-4-c... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00427766 CHEMBL294884 Bioactive pyrrollylactam indolinone driv. 16b

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23968 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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