CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1438
Family Name Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-methoxy-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine] family
No. of Seeds 23 No. of Other Members 0
Family Centroid CFAMM00323469 Functional Category Bioactive
Superfamily Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,3-c]quinoline Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
Calcitonin gene-related peptide 1 Inhibitor Cizolirtine Family 3 15
PF-02545920 family 16 140
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-04YWC4... 2 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-1'-p... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7438180... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00323457 CHEMBL1829670 Bioactive 1'-(3-methylbutyl)-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323470 CHEMBL1829574 Bioactive 1'-(cyclohexylmethyl)-6-methoxy-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323463 CHEMBL1171554 Bioactive (6R)-6-methoxy-1-phenyl-1'-propan-2-ylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323469 CHEMBL1829577 Bioactive 1'-butyl-6-methoxy-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323456 CHEMBL1829671 Bioactive 1'-(3-methylbut-3-enyl)-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323462 CHEMBL1170769 Bioactive (6R)-6-methoxy-1'-(2-methylpropyl)-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323475 CHEMBL1170546 Bioactive AGN-PC-04YWC2
CFAMM00323455 CHEMBL1829580 Bioactive 6-methoxy-1'-(3-methylbutyl)-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323468 CHEMBL1829571 Bioactive 6-methoxy-1-phenyl-1'-(2-phenylethyl)spiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323461 CHEMBL259732 Bioactive 1'-butyl-6-methoxy-1-phenylspiro[6H-furo[3,4-c]pyrazole-4,4'-piperidine]
CFAMM00323474 CHEMBL1172689 Bioactive (6R)-1'-benzyl-6-methoxy-1-phenylspiro[6H-furo[3,4-c]pyrazole-4,4'-piperidine]
CFAMM00323454 CHEMBL1829581 Bioactive 6-methoxy-1'-(3-methylbut-3-enyl)-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323467 CHEMBL1829573 Bioactive 6-methoxy-1-phenyl-1'-(4-phenylbutyl)spiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323460 CHEMBL1829659 Bioactive 6-methoxy-1'-octyl-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323473 CHEMBL1829669 Bioactive 1'-benzyl-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323453 CHEMBL1169777 Bioactive (6R)-1'-benzyl-6-methoxy-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323466 CHEMBL1829572 Bioactive 6-methoxy-1-phenyl-1'-(3-phenylpropyl)spiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323459 CHEMBL1829568 Bioactive 1'-[(4-fluorophenyl)methyl]-6-methoxy-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323472 CHEMBL1829579 Bioactive 6-methoxy-1'-pentyl-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00323465 CHEMBL410832 Bioactive SureCN3002693
CFAMM00323458 CHEMBL1829566 Bioactive AGN-PC-04YVLD
CFAMM00323471 CHEMBL1829578 Bioactive AGN-PC-04YVLH
CFAMM00323464 CHEMBL1171555 Bioactive SureCN3008314

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27621 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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