CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14399
Family Name Beta-secretase 1 and Beta-secretase 2 inhibitor 3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]benzamide family
No. of Seeds 6 No. of Other Members 2
Family Centroid CFAMM00428279 Functional Category Bioactive
Superfamily Beta-secretase 1 and Beta-secretase 2 Binder Superfamily
Class Class 3128

Cousin Family NamesSeedsMembers
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-3 adrenergic receptor Ligand BMS-196085 Family 18 72
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Beta-secretase 1 and Cathepsin D inhibitor 3ixk family 2 9
Beta-secretase 1 and Cathepsin D inhibitor 3ixj family 10 21
Beta-secretase 1 inhibitor SureCN3599637 family 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Beta-secretase 1 and Cathepsin D inhibitor 3-(4-chloro-N-methy... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN5224847 ... 3 24
Pol polyprotein inhibitor AC1LA9K7 family 7 23
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00428282 CHEMBL595016 Bioactive CHEMBL595016
CFAMM00428279 CHEMBL427719 Bioactive 3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]benzamide
CFAMM00428283 CHEMBL595136 Bioactive CHEMBL595136

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27676 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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