CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1443
Family Name D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-PC-0886JJ family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00235300 Functional Category Bioactive with Natural Product
Superfamily D(2) dopamine receptor and Sodium-dependent serotonin transporter Binder Superfamily
Class Class 409

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Apricoxib family 8 77
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 36 18
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Glucocorticoid receptor and Progesterone receptor ligand AGN-P... 3 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
Sodium-dependent serotonin transporter inhibitor (2S)-1-[(2S,4... 7 1
D(2) dopamine receptor ligand SureCN10575660 family 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 4
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Glucagon receptor ligand SureCN2647807 family 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-[(... 1 0
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 2 2
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Prothrombin inhibitor AGN-PC-074I4K family 1 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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