CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14430
Family Name 72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)-2-butyl-4-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]-6-[4-(2-sulfamoylphenyl)phenyl]hexanoic acid family
No. of Seeds 5 No. of Other Members 8
Family Centroid CFAMM00428472 Functional Category Bioactive
Superfamily 72 kDa type IV collagenase and Collagenase 3 Binder Superfamily 2
Class Class 1866

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Neprilysin Inhibitor Thiorphan Family 41 68
Neuromedin-K receptor Ligand Senktide Family 15 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 14 2
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Squalene synthase inhibitor (2R)-2-[2-[[(2S,3S)-4-(3,4-dichlor... 6 9
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Neprilysin inhibitor SureCN489232 family 3 9
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Neprilysin inhibitor (2S)-2-[[1-[3-(4-fluorophenyl)propylcarba... 2 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Neprilysin inhibitor SureCN7437961 family 2 6
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Neprilysin inhibitor (2R,4R)-4-(4-carboxybutanoylamino)-2-meth... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00428480 CHEMBL267503 Bioactive (2S,4R)-2-butyl-6-[4-[2-(tert-butylsulfamoyl)phenyl]phenyl]-4-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]hexanoic acid
CFAMM00428472 CHEMBL266294 Bioactive (2S,4R)-2-butyl-4-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]-6-[4-(2-sulfamoylphenyl)phenyl]hexanoic acid
CFAMM00428475 CHEMBL269613 Bioactive (2S,4R)-2-butyl-4-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]-6-[4-(4-methylsulfanylphenyl)phenyl]hexanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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