CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14433
Family Name Melanin-concentrating hormone receptor 1 and Cytochrome P450 3A4 ligand 1-[(2-fluorophenyl)methyl]-3-(3-methoxyphenyl)-8-[[4-(4-methoxypyridin-3-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00428488 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily 5
Class Class 2472

Cousin Family NamesSeedsMembers
Histamine H3 receptor and Cytochrome P450 3A4 ligand SureCN822... 3 7
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Melanin-concentrating hormone receptor 1 ligand 3-[4-[[3-(3-me... 2 10
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[(2R)-2-amino... 1 1


External ID

Functional Category

Molecule Name

CFAMM00428486 CHEMBL389809 Bioactive 5-[4-[[1-[(2-fluorophenyl)methyl]-3-(3-methoxyphenyl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenyl]pyridine-3-carbonitrile
CFAMM00428488 CHEMBL266513 Bioactive 1-[(2-fluorophenyl)methyl]-3-(3-methoxyphenyl)-8-[[4-(4-methoxypyridin-3-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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