CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1447
Family Name Macrophage colony-stimulating factor 1 receptor ligand SureCN1855955 family
No. of Seeds 28 No. of Other Members 9
Family Centroid CFAMM00323664 Functional Category Bioactive
Superfamily Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole Analogue Superfamily
Class Class 930

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
BIBT986 family 7 96
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 6-im... 2 30
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Motilin receptor and Growth hormone secretagogue receptor type... 2 2
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... 1 1
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00323652 CHEMBL1171604 Bioactive SureCN1860359
CFAMM00323665 CHEMBL1171777 Bioactive SureCN1857203
CFAMM00323658 CHEMBL1169980 Bioactive AGN-PC-0886F6
CFAMM00323651 CHEMBL1171607 Bioactive AGN-PC-015GVT
CFAMM00323664 CHEMBL1170786 Bioactive SureCN1855955
CFAMM00323657 CHEMBL1171385 Bioactive SureCN1864639
CFAMM00323650 CHEMBL1171606 Bioactive SureCN1856332
CFAMM00323663 CHEMBL1170785 Bioactive SureCN12408087
CFAMM00323669 CHEMBL2158301 Bioactive N-[4-[1-(2-amino-2-methylpropanoyl)piperidin-4-yl]-2-(cyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamide
CFAMM00323649 CHEMBL2158221 Bioactive 5-cyano-N-[2-(cyclohexen-1-yl)-4-piperidin-4-ylphenyl]-1H-imidazole-2-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00323662 CHEMBL1170784 Bioactive SureCN1857854
CFAMM00323655 CHEMBL2158290 Bioactive 5-cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-methylsulfonylacetyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamide
CFAMM00323668 CHEMBL257154 Bioactive 5-cyano-N-[2-(cyclohexen-1-yl)-4-piperidin-4-ylphenyl]-1H-imidazole-2-carboxamide
CFAMM00323661 CHEMBL402337 Bioactive 5-cyano-N-[2-(4-methylcyclohexen-1-yl)-4-piperidin-4-ylphenyl]-1H-imidazole-2-carboxamide
CFAMM00323667 CHEMBL1169979 Bioactive 5-cyano-N-[4-(2-cyanoimino-1,3-dimethyl-1,3-diazinan-5-yl)-2-(4,4-dimethylcyclohexen-1-yl)phenyl]-1H-imidazole-2-carboxamide
CFAMM00323660 CHEMBL1170997 Bioactive AGN-PC-0886F5
CFAMM00323653 CHEMBL1171605 Bioactive SureCN1860908
CFAMM00323666 CHEMBL256950 Bioactive 5-cyano-N-[2-(cyclopenten-1-yl)-4-piperidin-4-ylphenyl]-1H-imidazole-2-carboxamide
CFAMM00323659 CHEMBL256712 Bioactive N-[4-(1-acetylpiperidin-4-yl)-2-(cyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

43706 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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