CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14483
Family Name D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR,12bS)-3-propyl-5,6,6a,7,8,12b-hexahydronaphtho[1,2-f][1,7]naphthyridine-10,11-diol family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00428719 Functional Category Bioactive
Superfamily Lethal factor and D(2) dopamine receptor Binder Superfamily
Class Class 2081

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Tumor necrosis factor receptor superfamily member 5 Ligand Dac... 48 288
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 9 12
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Transient receptor potential cation channel subfamily V member... 1 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aS... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00428719 CHEMBL26965 Bioactive (6aR,12bS)-3-propyl-5,6,6a,7,8,12b-hexahydronaphtho[1,2-f][1,7]naphthyridine-10,11-diol
CFAMM00428723 CHEMBL281932 Bioactive (6aR,12bS)-5,6,6a,7,8,12b-hexahydronaphtho[1,2-f][1,7]naphthyridine-10,11-diol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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