CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14497
Family Name Prostaglandin G/H synthase 2 inhibitor 6-ethoxy-2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00428780 Functional Category Bioactive
Superfamily Prostaglandin G/H synthase 2 and Fructose-1,6-bisphosphatase 1 Binder Superfamily
Class Class 380

Cousin Family NamesSeedsMembers
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Prostaglandin G/H synthase 2 inhibitor 2-(4-methylsulfonylphen... 1 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 0


External ID

Functional Category

Molecule Name

CFAMM00428784 CHEMBL271549 Bioactive 6-(2-methoxyethoxy)-2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
CFAMM00428783 CHEMBL270293 Bioactive 6-methoxy-2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
CFAMM00428782 CHEMBL271348 Bioactive 6-cyclopentyloxy-2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
CFAMM00428781 CHEMBL271932 Bioactive N-benzyl-6-methoxy-2-(4-methylsulfonylphenyl)pyrimidin-4-amine
CFAMM00428780 CHEMBL271173 Bioactive 6-ethoxy-2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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