CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14501
Family Name Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00393302 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin B Binder Superfamily 3
Class Class 3128

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Pol polyprotein inhibitor 180968-31-4 family 8 13
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(4-me... 2 9
Substance-P receptor ligand (1S,2R,5aS,7R,8aR,8bS)-2-[(1R)-1-[... 11 15
Substance-P receptor ligand (1S,2R,5aS,7S,8aR,8bS)-7-amino-2-[... 12 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonyl... 2 0
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 1 2
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 9
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Pol polyprotein inhibitor 152928-55-7 family 23 2
Pol polyprotein inhibitor AC1NUKPV family 4 13
Cathepsin B and Cathepsin L1 inhibitor 3-[[(2R)-2-cyano-2-[[(2... 3 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Pol polyprotein inhibitor KNI-1279 family 3 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Pol polyprotein inhibitor AC1LA3AI family 5 9
Pol polyprotein inhibitor AC1LAMTC family 6 0
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Plasmepsin-1 and Plasmepsin-2 inhibitor N-[(2S,3S)-5-[[(2S)-1-... 2 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Pol polyprotein inhibitor AC1LAEYH family 2 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Beta-secretase 1 inhibitor SureCN8292004 family 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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