CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14514
Family Name Tyrosine-protein kinase Lck and Vascular endothelial growth factor receptor 2 ligand N-(2,6-dimethylphenyl)-1-[4-(3,4,5-trimethoxyanilino)-1,3,5-triazin-2-yl]benzimidazol-2-amine family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00393496 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Beta-lactamase Binder Superfamily
Class Class 2504

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
D(4) dopamine receptor Ligand A-425444 Family 2 10
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VO0 family 1 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Glutaminyl-peptide cyclotransferase inhibitor 1-(3,4-dimethoxy... 1 17
Receptor-type tyrosine-protein kinase FLT3 ligand 1-phenyl-3-N... 2 2
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
C-X-C chemokine receptor type 3 ligand (6aR,9R)-9-N,9-N-diethy... 1 7


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27046 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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