CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14530
Family Name Vascular endothelial growth factor receptor 2 ligand N-(4-chlorophenyl)-6-quinolin-4-yloxynaphthalene-1-carboxamide family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00428947 Functional Category Bioactive
Superfamily Vasopressin V2 receptor and Vasopressin V1a receptor Binder Superfamily 2
Class Class 3170

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
DNA Binder Primaquine Family 3 245
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Tivozanib family 4 6
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
B2 bradykinin receptor ligand SureCN8516699 family 3 2
B2 bradykinin receptor ligand SureCN6640854 family 7 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QHF0 family 3 1
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Somatostatin receptor type 2 ligand SureCN4325675 family 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 11 8
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 3
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 0
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Metabotropic glutamate receptor 2 ligand 8-chloro-6-[4-[(6-chl... 9 0
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00428943 CHEMBL272827 Bioactive N-(4-chlorophenyl)-6-[2-(methylamino)pyridin-4-yl]oxynaphthalene-1-carboxamide
CFAMM00428948 CHEMBL273062 Bioactive N-(4-chlorophenyl)-6-(7-methoxyquinolin-4-yl)oxynaphthalene-1-carboxamide
CFAMM00428947 CHEMBL273064 Bioactive N-(4-chlorophenyl)-6-quinolin-4-yloxynaphthalene-1-carboxamide
CFAMM00428946 CHEMBL271181 Bioactive 4-[5-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl]oxy-N-methylpyridine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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