CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14534
Family Name Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00428958 Functional Category Bioactive
Superfamily Prelamin-A/C and Progesterone receptor Binder Superfamily 2
Class Class 3683

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Triprolidine Family 19 316
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Glucocorticoid receptor and Oxysterols receptor LXR-alpha Liga... 4 13
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Smoothened homolog inhibitor AC1P6IWE family 1 0
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 35
5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Glucocorticoid receptor ligand (4aR)-1-(4-fluorophenyl)-4a-(me... 18 2
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
Glucocorticoid receptor ligand 4-[[(4aS)-6-(4-tert-butylphenyl... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Transient receptor potential cation channel subfamily V member... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00428959 CHEMBL403178 Bioactive 1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-N-phenyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline-6-sulfonamide
CFAMM00428958 CHEMBL271263 Bioactive 6-benzyl-1-(4-fluorophenyl)-4a-[(4-fluorophenyl)methyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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