CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14552
Family Name Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chlorophenyl)-1-methylbenzimidazole-5-carbonitrile family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00429009 Functional Category Bioactive
Superfamily Smoothened homolog and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 2257

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Histamine H1 receptor Ligand Mizolastine Family 14 603
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Transient receptor potential cation channel subfamily V member... 4 0
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Pteridine reductase, putative inhibitor 1-[(3,4-dichlorophenyl... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429009 CHEMBL272114 Bioactive 7-(aminomethyl)-6-(2-chlorophenyl)-1-methylbenzimidazole-5-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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