CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14556
Family Name CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]methyl]piperazin-1-yl]ethanone family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00429023 Functional Category Bioactive
Superfamily Gp29 Inhibitor Tmpyp4 Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
HIV protease Inhibitor Saquinavir Family 64 428
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
26S proteasome Inhibitor Bortezomib Family 7 65
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Serine/threonine-protein kinase mTOR and DNA-dependent protein... 6 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Cathepsin K inhibitor SureCN2155973 family 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Telomerase reverse transcriptase inhibitor N-[9-(4-aminoanilin... 1 11
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
D(4) dopamine receptor ligand SureCN4006627 family 1 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
8'-fluoro-6'-methyl-2,3,4,5',6',9-hexahydrodispiro[beta-carbol... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429023 CHEMBL272361 Bioactive 1-[4-acetyl-3-[[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]methyl]piperazin-1-yl]ethanone
CFAMM00429022 CHEMBL401546 Bioactive 1-(azetidin-1-yl)-2-[4-[5-(4-fluorophenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]piperidin-1-yl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24732 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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