CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14566
Family Name Metabotropic glutamate receptor 5 ligand 3-methyl-1-(2-thiophen-3-ylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00429050 Functional Category Bioactive
Superfamily Cytochrome P450 3A4 and Cytochrome P450 11B1, mitochondrial Binder Superfamily
Class Class 1800

Cousin Family NamesSeedsMembers
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429051 CHEMBL403390 Bioactive 3-methyl-1-(2-thiophen-3-ylethynyl)pyrrolo[1,2-a]pyrazine-7-carbonitrile
CFAMM00429050 CHEMBL272800 Bioactive 3-methyl-1-(2-thiophen-3-ylethynyl)-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27286 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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