CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14575
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand (4-cyclopropyl-1,4-diazepan-1-yl)-[4-(3-methoxyphenoxy)-3-(methylaminomethyl)phenyl]methanone family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00044611 Functional Category Bioactive
Superfamily Peroxisome proliferator-activated receptor gamma and Peroxisome proliferator-activated receptor alpha Ligand KRP-297 Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Histamine H3 receptor Ligand A-317920 Family 9 240
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC20762875 Family 7 1
4-methyl-7-[(4-methylpiperazin-1-ium-1-yl)methyl]-3-oxo-1-benz... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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