CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14582
Family Name Pol polyprotein inhibitor AC1LA3AI family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00429143 Functional Category Bioactive
Superfamily Pol polyprotein Binder Superfamily 41
Class Class 880

Cousin Family NamesSeedsMembers
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
HIV-1 protease Inhibitor Nelfinavir Family 11 26
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Thymopentin family 20 133
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
cAMP-dependent protein kinase type II-beta regulatory subunit ... 34 81
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Tyrosinase Inhibitor N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenz... 3 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 2 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Transient receptor potential cation channel subfamily V member... 3 18
Prothrombin inhibitor (2S)-N-[(4-aminocyclohexyl)methyl]-1-[2-... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Gamma-aminobutyric acid type B receptor subunit 1 ligand CGP-6... 3 0
Pol polyprotein inhibitor KNI-1279 family 3 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Pol polyprotein inhibitor 2,5-bis[(2-{[(benzyloxy)carbonyl]ami... 2 3
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor 168912-67-2 family 1 0
Pol polyprotein inhibitor AC1LA3C0 family 2 18
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Pol polyprotein inhibitor AC1LA3B0 family 1 2
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0
Pol polyprotein inhibitor AC1LA3AU family 1 0
Pol polyprotein inhibitor AC1LA3CC family 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 4
Beta-secretase 1 inhibitor 3-[[[(2S)-2-[[(3S,4S)-3-hydroxy-6-m... 2 4
Glutamate carboxypeptidase 2 inhibitor 2-(4-hydroxy-3-methoxyp... 1 4
Beta-lactamase inhibitor CHEMBL1316873 family 1 1
Calpain-1 catalytic subunit inhibitor (2E)-2-[(3,4-dihydroxyph... 4 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Benzamides Metabolite Chymosin preparation, escherichia coli k... 1 4
Putative NP ZINC20611663 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429144 CHEMBL93540 Bioactive AC1LA3AF
CFAMM00429137 CHEMBL273562 Bioactive AC1LA3AC
CFAMM00429143 CHEMBL328531 Bioactive AC1LA3AI
CFAMM00429136 CHEMBL327611 Bioactive AC1LA3AL
CFAMM00429146 CHEMBL93718 Bioactive AC1LA3B3

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24328 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543