CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14584
Family Name Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R)-3-(2-chloro-1H-indol-3-yl)-2-[[2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoic acid family
No. of Seeds 17 No. of Other Members 10
Family Centroid CFAMM00145690 Functional Category Bioactive with Natural Product
Superfamily Prothrombin and Endothelin-1 receptor Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
(1S)-2-(2-chloroacetyl)-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]i... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00429161 CHEMBL307903 Bioactive 2-[[(2R)-3-(2-chloro-1H-indol-3-yl)-2-[[2-cyclopropyl-2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]acetyl]amino]propanoyl]amino]hexanoic acid
CFAMM00429154 CHEMBL310111 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[4-methyl-2-[(2-methylpiperidine-1-carbonyl)amino]pentanoyl]amino]propanoyl]amino]hexanoic acid
CFAMM00429167 CHEMBL424422 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]hexanoic acid
CFAMM00429160 CHEMBL306977 Bioactive 2-[[(2R)-3-(2-chloro-1H-indol-3-yl)-2-[2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]hexanoylamino]propanoyl]amino]hexanoic acid
CFAMM00429153 CHEMBL73925 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-cyclopropyl-2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]acetyl]amino]propanoyl]amino]hexanoic acid
CFAMM00429159 CHEMBL449962 Bioactive 2-[[(2R)-3-(2-chloro-1H-indol-3-yl)-2-[[3-cyclopropyl-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]propanoyl]amino]propanoyl]amino]hexanoic acid
CFAMM00429157 CHEMBL74000 Bioactive 2-[[(2R)-3-(2-chloro-1H-indol-3-yl)-2-[[2-cyclopentyl-2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]acetyl]amino]propanoyl]amino]hexanoic acid
CFAMM00429163 CHEMBL77853 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]pent-4-enoic acid
CFAMM00429156 CHEMBL284250 Bioactive (2S)-2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[(2S)-2-cyclopropyl-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]acetyl]amino]propanoyl]amino]hexanoic acid
CFAMM00429169 CHEMBL308815 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]pentanoic acid
CFAMM00429162 CHEMBL289349 Bioactive (2S)-2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]hexanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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