CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1460
Family Name Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte growth factor receptor ligand 2-[2-amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-6-methyl-1,3-benzoxazol-5-ol;2,2,2-trifluoroacetic acid family
No. of Seeds 7 No. of Other Members 56
Family Centroid CFAMM00323791 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Mitogen-activated protein kinase kinase kinase 7 Binder Superfamily
Class Class 918

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
Prothrombin inhibitor SureCN6931925 family 3 0
Hepatocyte growth factor receptor ligand 2-[2-amino-5-(1-piper... 4 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Mitogen-activated protein kinase kinase kinase 7 and TGF-beta-... 3 14
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1


External ID

Functional Category

Molecule Name

CFAMM00323794 CHEMBL2032278 Bioactive 2-[2-amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-6-ethyl-1,3-benzoxazol-5-ol;2,2,2-trifluoroacetic acid
CFAMM00323792 CHEMBL2032277 Bioactive 2-[2-amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-4,6-dimethyl-1,3-benzoxazol-5-ol;2,2,2-trifluoroacetic acid
CFAMM00323791 CHEMBL2032276 Bioactive 2-[2-amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-6-methyl-1,3-benzoxazol-5-ol;2,2,2-trifluoroacetic acid
CFAMM00323811 CHEMBL2032285 Bioactive 2-[2-amino-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-3-yl]-1,3-benzoxazol-6-amine;2,2,2-trifluoroacetic acid
CFAMM00323789 CHEMBL1170926 Bioactive AGN-PC-0886AZ
CFAMM00323822 CHEMBL2032155 Bioactive 5-(1-piperidin-4-ylpyrazol-4-yl)-3-(7-pyridin-2-yl-1,3-benzoxazol-2-yl)pyridin-2-amine;2,2,2-trifluoroacetic acid
CFAMM00323775 CHEMBL1171941 Bioactive AGN-PC-080TPK

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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