CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM14623
Family Name Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ligand SureCN5861382 family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00239411 Functional Category Bioactive with Natural Product
Superfamily Squalene monooxygenase Inhibitor Tolnaftate Superfamily
Class Class 615

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Peroxisome proliferator-activated receptor gamma Ligand Rosigl... 1 2
Substance-P receptor Ligand Ezlopitant Family 10 207
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Mineralocorticoid receptor and Androgen receptor Ligand LGD-55... 6 6
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Renin Inhibitor Ro-66-1168 Family 10 30
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Progesterone receptor and Glucocorticoid receptor ligand AGN-P... 6 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Transient receptor potential cation channel subfamily V member... 3 15
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 2 1
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 23 10
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
Somatostatin receptor type 1 and D(4) dopamine receptor ligand... 9 10
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Androgen receptor ligand 10-(hydroxymethyl)-4-methyl-1,5-dihyd... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Substance-P receptor ligand CP 141938 family 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8797835 f... 1 15
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
D(3) dopamine receptor ligand rac S 33138 family 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Histamine H3 receptor ligand SureCN3057839 family 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor KF 17828 family 4 11
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8797384 f... 1 0
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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